Research

Research focus: to understand the disease mechanisms of age-related macular degeneration as manifested in the retinal pigmented epithelium (RPE) cell layer in the eye. 

Publications

• Striebel, J. F., Carroll, J. A., Race, B., Leung, J. M., Schwartz, C., Reese, E. D., Rickman, C. B., Chesebro, B., & Klingeborn, M. (2024). The Prion Protein Is Required for Normal Responses to Light Stimuli by Photoreceptors and Bipolar Cells. iScience. https://doi.org/10.1016/j.isci.2024.110954
• Hanke-Gogokhia, C., Zapadka, T. E., Finkelstein, S., Klingeborn, M., Maugel, T. K., Singer, J. H., Arshavsky, V. Y., & Demb, J. B. (2024). The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Journal of Neuroscience. https://doi.org/10.1523/JNEUROSCI.1379-23.2024
• Hernandez, B. J., Skiba, N. P., Plössl, K., Strain, M., Liu, Y., Grigsby, D., Kelly, U., Cady, M. A., Manocha, V., Maminishkis, A., Watkins, T., Miller, S. S., Ashley-Koch, A., Stamer, W. D., Weber, B. H., Bowes Rickman, C., & Klingeborn, M. (2023). Polarized Desmosome and Hemidesmosome Shedding via Small Extracellular Vesicles Is an Early Indicator of Outer Blood-Retina Barrier Dysfunction. Journal of Extracellular Biology. https://doi.org/10.1002/jex2.116
• Grigsby, D., Klingeborn, M., Kelly, U., Chew, L. A., Asokan, A., Devlin, G., Smith, S., Keyes, L., Timmers, A., Scaria, A., & Bowes Rickman, C. (2023). AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model. Investigative Ophthalmology & Visual Science. https://doi.org/10.1167/iovs.64.10.25

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