Vasudeva G Kamath, PhD
Assistant Professor of Biochemistry, Department of Basic Sciences
Dr. Kamath’s began his research career by investigating hyperglycemia caused by the indiscriminate use of insecticides, where he demonstrated the adverse effect of organophosphate insecticides such as dimethoate and dichlorvos in disturbing pancreatic function in rats and rendering them sensitive to the oral glucose tolerance test. Further in his postdoctoral research career he was associated with a laboratory at Wayne State University; dedicated to understanding the signaling events leading to insulin secretion in beta cells. There he examined the role of histidine phosphatase and prenyl-transferase in glucose stimulated insulin secretion. Thereafter as a Fixed-term Faculty, he was associated with Dr. McKee’s research group at Central Michigan University and was involved in delineating and understanding the basic biochemical pathways of nucleoside metabolism and the extent of damage caused by antiretroviral compounds employing gene expression analysis.
He taught at the Department of Foundational Sciences, College of Medicine, Central Michigan University, Mount Pleasant, MI, USA.
trained in various pedagogy methods that involved facilitating the small group of medical students in problem based learning (PBL), integrated community experiences (ICE), writing cases for case based learning (CBL) and developing team based learning modules in several organ systems (Gastro Intestinal, Musculoskeletal/Dermatology, Reproduction and Hematology/Oncology). Helped develop new integrated medical curriculum at the newly started College of Medicine, Central Michigan University.
Biochemistry I (BSCI-603-M)
Biochemistry II (BSCI-605-M)
Post Doctoral Fellow (Aug 2010 – Oct 2011)
Indiana University School of Medicine, South Bend, IN, USA
Post Doctoral Fellow (Nov 2008 – Jul 2010)
Dept. of Pharmaceutical Science, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Ph.D (Biochemistry), Mysore University, Mysore, India (Apr 2008)
Conducted research at Central Food Technological Research Institute (CFTRI), Mysore, India
M.Sc. (Medical) Biochemistry, Kasturba Medical College, Manipal, India (July 2001) Preliminary subjects: Human Anatomy and Physiology
B.Sc. (Chemistry, Botany & Microbiology), St. Aloysius College, Mangalore University, Mangalore, India (June 1998)
October 6th 2011- June 30th 2015: Fixed-term Faculty at Department of Foundational Sciences, College of Medicine, Central Michigan University, Mount Pleasant, MI, USA.
Eck Institute for Global Health, University of Notre Dame, Indiana, USA
United Mitochondrial Disease Foundation, Pittsburgh, Pennsylvania, USA
International Society of Antiviral Research, USA
The American Society for Cell Biology, Bethesda, Maryland, USA
Editorial Board Member of Pancreas Open Journal (Openventio)
Senior Research Fellow Grant was awarded by Indian Council of Medical Research, New Delhi, India. 07/1/2004 -- 06/30/2007
Areas of Research/Interest
My laboratory research focusses on understanding the nucleoside metabolic pathways which are also involved in the metabolism of nucleoside analogue drugs used in the treatment of retroviral infections. Most recently our team at Central Michigan University studied the thymidine salvage mechanisms in mitochondrial matrix and have established the possible compartmentalization of the thymidylate within mitochondrial matrix.
- Vazquez EJ, Berthiaume JM, Kamath V, Achike O, Buchanan E, Montano MM, Chandler MP, Miyagi M, Rosca MG. (2015) Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. Cardiovasc Res. 2015 Jun 22. pii: cvv183. [Epub ahead of print]
- Kamath VG, Hsiung C-H, Lizenby ZJ and McKee EE (2014) Heart Mitochondrial TTP Synthesis and the Compartmentalization of TMP. J Biol Chem doi:10.1074/jbc.M114.624213
- Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A. (2010) Regulation of glucose-and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic β-cells. Am J Physiol Endocrinol Metab 299(2), E276-286.
- Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. (2010) Protein farnesylation-dependent raf/erk signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic β-cells. Diabetes59, 967-977.
- Goalstone M, Kamath V, Kowluru A. (2010) Glucose activates prenyltransferases in pancreatic islet beta-cells. Biochemical and Biophysical Research Communication, 391(1):895-898.
- Singh N, Kamath V, Narasimhamurthy K, Rajini PS. (2008) Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats. Environmental Toxicology and Pharmacology 26(2), 241-244.
- Kamath V, Joshi AKR, Rajini PS. (2008) Biochemical perturbations in rat pancreas induced by dimethoate an organophorsphorous insecticide and its attenuation by cashew skin extract. Pesticide Biochemistry and Physiology 90, 58-65.
- Kamath V, Rajini PS. (2007) Altered glucose homeostasis and oxidative impairment in pancreas of rats subjected to dimethoate intoxication. Toxicology 231, 137-146.
- Kamath V, Rajini P S (2007) The efficacy of Cashew nut (Anacardium occidentale L) skin extract as a free radical scavenger. Food Chemistry 103, 428-433.
- Kamath V, Niketh S, Chandrashekar A, Rajini PS. (2007) Chymotryptic hydrolysates of α-kafirin, the storage protein of sorghum (Sorghum bicolor) exhibited Angiotensin converting enzyme inhibitory activity. Food Chemistry 100(1), 306-311.
- Kamath V, Rajini PS, Lohith K, Somashekar BR, Diwakar S. (2006) Angiotensin converting enzymes inhibitory activity of amino acid esters of carbohydrates. International Journal of Biological Macromolecules 38, 89-93.
- Singh N, Kamath V, Rajini PS (2005) Protective effect of potato peel powder in ameliorating oxidative stress in streptozotocin diabetic rats. Plant Foods for Human Nutrition 60, 49-54.
- Singh N, Kamath V, Rajini PS (2005) Attenuation of hyperglycemia and associated biochemical parameters in STZ-induced diabetic rats by dietary supplementation of potato peel powder Clinica Chimica Acta 353, 165-175.
- Kamath V, Chandrashekar A, Rajini PS (2004) Antiradical properties of sorghum (Sorghum bicolor L. Moench) flour extracts. Journal of Cereal Science 40, 283-288.
Central Michigan University Niijkewehn Mentoring Program for American Indian youth.