Sankhavaram R. Panini, PhD

Professor of Biochemistry, Department of Basic Biomedical Sciences

  • Office: 60 Prospect Avenue, 2nd Floor, Room 251
  • Campus:
    Touro College of Osteopathic Medicine - Middletown
  • Phone:
    (845)648-1263
  • Email:
    sankhavaram.panini@touro.edu

Dr. Panini received his PhD degree from Indian Institute of Science, Bangalore, India. After postdoctoral training in the laboratory of Prof. Harry Rudney at University of Cincinnati, he held research positions at Eleanor Roosevelt Institute of Cancer Research, Denver, CO and at East Tennessee State University. He taught Biochemistry to medical, graduate, and PA students at ETSU, Johonson City, TN; Emory University, Atlanta; and at MUA, Nevis, WI. He is also the author of the textbook, Medical Biochemistry: An Illustrated Review, 2013, Thieme Publishers, NY.

Office Hours

By appointment

Education/Training

1968, B.Sc., Andhra University, Waltair, India

1970, M.Sc., M.S. University of Baroda, Baroda, India

1971, D.I.I.Sc., Indian Institute of Science, Bangalore, India

1975, Ph.D., Indian Institute of Science, Bangalore, India

Professional Affiliations

American Society of Biochemistry and Molecular Biology, 1991-current

American Heart Association, Council on Arteriosclerosis, Thrombosis & Vascular Biology, 1993-current

International Association of Medical Science Educators 2004-current

Association of Biochemistry Course Directors, 2009-current 

Fellowships/Honors

National Science Talent Search Scholarship award of the National Council of Educational Research and Training, Ministry of Education, Govt of India, 1965-1974

Alec E. Hodel Excellence in Teaching Award for 2006-2007 from the Dept. of Biochemistry, Emory University School of Medicine, Atlanta, GA

Dean’s Teaching Award for Teaching Excellence,  2008, Emory University School of Medicine, Atlanta, GA

Courses Taught

Biochemistry I (BSCI-603-M)

Biochemistry II (BSCI-605-M)

Areas of Research

Early events in atherogenesis leading to the formation and apoptosis of foam cells.

Grants/Funding

1986-1987  “Regulation of Plasma Cholesterol” Grant-in-aid (SW 8621) from the Southwestern Ohio Chapter of the American Heart Association.

1989-1990  “Pharmacological Modulation of Hepatic Lipoprotein Receptors and Cholesterol Metabolism.”  Grant-in-aid (90 827) from the American Heart Association of Colorado.

1990-1994  “Endogenous Regulators of Isoprenoid Biosynthesis.”  Research grant         (RO1 DK42270) from the National Institutes of Health.

1992-1995  “Biological Actions of 24(S), 25-Oxidolanosterol.”   Research grant (#3401) from the Council for Tobacco Research, Inc.

1994-1995  “Effects of Calcium Antagonists on Cholesterol and Lipoprotein Metabolism.”  Grant-in-aid (CO-GS-47-94) from the American Heart Association of Colorado

1994-1996  “Growth Regulation of Breast Cancer Cells by Natural Steroidal Anti-estrogens.”   Grant-in-aid from Dale Tooley Cancer Research Laboratory Fund.

1997-1998  “Analysis of Gene Expression in Macrophage Foam Cells.” Grant-in-aid from the Research Development Committee, ETSU

1998-2000  “Differential Gene Expression in Macrophage Foam Cells.” Research         Grant from Rhône-Poulenc Rorer Pharmaceuticals, Inc.

1998-2001  “Modulation of Foam Cell-Specific Gene Expression: Implications for Atherogenesis.”  Grant-in-aid from the Southern Consortium, American Heart Association.

Selected Publications

Panini, Sankhavaram R. (2013) Medical Biochemistry – An Illustrated Review.  Thieme Publishers, New York, N.Y. ISBN: 978-1-60406-316-5.

Rusinol, A., Thewke, D., Liu J., Freeman, N., Panini, S.R., and Sinensky, M. (2004) Akt/Protein kinase B regulation of Bcl family members during oxysterol-induced apoptosis.  J. Biol. Chem. 279:1392-1399.

Panini, S.R., Yang, L., Rusinol, A.E., Sinensky, M.S., Bonventre, J.V. and Leslie, C.C. (2001) Arachidonate  metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. J. Lipid Res. 42:1678-1686.

Thewke, D.P., Panini, S.R. and Sinensky, M. (1998) Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding protein. J. Biol. Chem. 273:21402-21407.

Invited Presentations

  1. Dept. of Nutrition, University of California, Davis, “Translational control of HMG-CoA reductase,” Astra-Merck Lecture, 1995
  2. Rhone-Poulenc Rorer Pharmaceuticals, King of Prussia, PA, “Differential display analysis of gene expression in human macrophage foam cells,” 1998
  3. Internal Medicine Seminar Series, ETSU, “PP-2A and foam cell apoptosis,” 2001
  4. Center for Scientific Review, NIH, “Mechanisms of oxysterol-induced apoptosis,” 2004