Sankhavaram R. Panini, PhD
Professor of Biochemistry, Department of Basic Biomedical Sciences
Dr. Panini received his PhD degree from Indian Institute of Science, Bangalore, India. After postdoctoral training in the laboratory of Prof. Harry Rudney at University of Cincinnati, he held research positions at Eleanor Roosevelt Institute of Cancer Research, Denver, CO and at East Tennessee State University. He taught Biochemistry to medical, graduate, and PA students at ETSU, Johonson City, TN; Emory University, Atlanta; and at MUA, Nevis, WI. He is also the author of the textbook, Medical Biochemistry: An Illustrated Review, 2013, Thieme Publishers, NY.
1968, B.Sc., Andhra University, Waltair, India
1970, M.Sc., M.S. University of Baroda, Baroda, India
1971, D.I.I.Sc., Indian Institute of Science, Bangalore, India
1975, Ph.D., Indian Institute of Science, Bangalore, India
American Society of Biochemistry and Molecular Biology, 1991-current
American Heart Association, Council on Arteriosclerosis, Thrombosis & Vascular Biology, 1993-current
International Association of Medical Science Educators 2004-current
Association of Biochemistry Course Directors, 2009-current
National Science Talent Search Scholarship award of the National Council of Educational Research and Training, Ministry of Education, Govt of India, 1965-1974
Alec E. Hodel Excellence in Teaching Award for 2006-2007 from the Dept. of Biochemistry, Emory University School of Medicine, Atlanta, GA
Dean’s Teaching Award for Teaching Excellence, 2008, Emory University School of Medicine, Atlanta, GA
Biochemistry I (BSCI-603-M)
Biochemistry II (BSCI-605-M)
Areas of Research
Early events in atherogenesis leading to the formation and apoptosis of foam cells.
1986-1987 “Regulation of Plasma Cholesterol” Grant-in-aid (SW 8621) from the Southwestern Ohio Chapter of the American Heart Association.
1989-1990 “Pharmacological Modulation of Hepatic Lipoprotein Receptors and Cholesterol Metabolism.” Grant-in-aid (90 827) from the American Heart Association of Colorado.
1990-1994 “Endogenous Regulators of Isoprenoid Biosynthesis.” Research grant (RO1 DK42270) from the National Institutes of Health.
1992-1995 “Biological Actions of 24(S), 25-Oxidolanosterol.” Research grant (#3401) from the Council for Tobacco Research, Inc.
1994-1995 “Effects of Calcium Antagonists on Cholesterol and Lipoprotein Metabolism.” Grant-in-aid (CO-GS-47-94) from the American Heart Association of Colorado
1994-1996 “Growth Regulation of Breast Cancer Cells by Natural Steroidal Anti-estrogens.” Grant-in-aid from Dale Tooley Cancer Research Laboratory Fund.
1997-1998 “Analysis of Gene Expression in Macrophage Foam Cells.” Grant-in-aid from the Research Development Committee, ETSU
1998-2000 “Differential Gene Expression in Macrophage Foam Cells.” Research Grant from Rhône-Poulenc Rorer Pharmaceuticals, Inc.
1998-2001 “Modulation of Foam Cell-Specific Gene Expression: Implications for Atherogenesis.” Grant-in-aid from the Southern Consortium, American Heart Association.
Panini, Sankhavaram R. (2013) Medical Biochemistry – An Illustrated Review. Thieme Publishers, New York, N.Y. ISBN: 978-1-60406-316-5.
Rusinol, A., Thewke, D., Liu J., Freeman, N., Panini, S.R., and Sinensky, M. (2004) Akt/Protein kinase B regulation of Bcl family members during oxysterol-induced apoptosis. J. Biol. Chem. 279:1392-1399.
Panini, S.R., Yang, L., Rusinol, A.E., Sinensky, M.S., Bonventre, J.V. and Leslie, C.C. (2001) Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. J. Lipid Res. 42:1678-1686.
Thewke, D.P., Panini, S.R. and Sinensky, M. (1998) Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding protein. J. Biol. Chem. 273:21402-21407.
- Dept. of Nutrition, University of California, Davis, “Translational control of HMG-CoA reductase,” Astra-Merck Lecture, 1995
- Rhone-Poulenc Rorer Pharmaceuticals, King of Prussia, PA, “Differential display analysis of gene expression in human macrophage foam cells,” 1998
- Internal Medicine Seminar Series, ETSU, “PP-2A and foam cell apoptosis,” 2001
- Center for Scientific Review, NIH, “Mechanisms of oxysterol-induced apoptosis,” 2004