Jeffrey W. Karpen, PhD

Professor of Physiology, Associate Chair - Department of Basic Biomedical Sciences

  • Office: 60 Prospect Avenue, 2nd Floor, Room 230
  • Campus:
    Touro College of Osteopathic Medicine - Middletown
  • Phone:
  • Email:

Office Hours

By appointment


B.A., Biochemistry, University of Pennsylvania, 1979

Ph.D., Biochemistry, Cornell University, 1985

Postdoctoral Fellow in Cell Biology and Neurobiology, Stanford University School of Medicine, 1985-1990

Professional Affiliations

Editorial Board, Journal of General Physiology, 2002-present

Professional Societies: Biophysical Society; Society of General Physiologists; Association for Research in Vision and Ophthalmology; American Chemical Society; American Association for the Advancement of Science 


University of Pennsylvania: Benjamin Franklin Scholar, National Merit Scholar, 1975-1979

NIH Individual National Research Service Award, 1985-1988

Bank of America-Giannini Foundation Medical Research Fellowship, 1988-1989

University of Colorado School of Medicine Excellence in Teaching Award, 1994

OHSU School of Medicine Teaching Excellence Award (Graduate Education), 2008, 2009

OHSU School of Medicine Faculty Excellence in Education Award, 2009

OHSU Golden ROSE Award for Service Excellence, 2009

Guest Editor, Journal of General Physiology, Perspectives Series on “Cyclic Nucleotide Microdomains and Signaling Specificity”, January 2014 issue

Courses Taught

Physiology, BSCI-635-M

Areas of Research

Signaling by intracellular second messengers, visual transduction, ion channel biophysics and chemical biology


National Institutes of Health / National Eye Institute, R01 EY009275, P.I. - Jeffrey W. Karpen, “Function and regulation of ion channels in retinal rods”, 8/1/91 to 11/30/11.

National Institutes of Health / National Institute of Mental Health, R01 MH071625, P.I. - Jeffrey W. Karpen, “Resolution of membrane localized cAMP signals in neurons”, 5/5/09 to 4/30/12.

Medical Research Foundation of Oregon, P.I. – Jeffrey W. Karpen, “Cyclic nucleotide-gated ion channels in physiology and disease”, 12/1/11 to 6/30/12.

Presidential Bridge Funding Award, Oregon Health & Science University, P.I. - Jeffrey W. Karpen, 2007.

National Institutes of Health / National Institute of Neurological Disorders and Stroke, R01 NS28389, P.I. - Dermot M.F. Cooper, Co.I. - Jeffrey W. Karpen, “Intracellular calcium control of cAMP synthesis”, 3/1/96 to 8/31/02.

Selected Publications

Click ‌here to view Dr. Karpen's Selected Publications

Invited Presentations

Biophysical Society Meeting, Minisymposium - Photorelease Techniques, Phoenix, Arizona, 1988.

International School of Biophysics - Sensory Transduction, Erice, Italy, 1988.

FASEB Summer Research Conference - The Biology and Chemistry of Vision, Saxton's River, Vermont, 1989.

Cornell University - Biophysics Seminar, Ithaca, New York, 1989.

University of California at San Francisco - Department of Ophthalmology and Retinitis Pigmentosa Research Center, San Francisco, California, 1990.

Colorado State University - Program in Neuronal Growth & Development, Fort Collins, Colorado, 1991.

University of Colorado Health Sciences Center - Department of Pharmacology, Denver, Colorado, 1993.

Max Planck Institut für Medizinische Forschung, Heidelberg, Germany, 1994.

Physiological Society Meeting, Symposium - Ion Channels Gated by Cyclic Nucleotides, London, England, 1995. 

University of Wisconsin Medical School - Department of Neurophysiology, Madison, Wisconsin, 1996.

Brown University - Neuroscience Program , Providence, Rhode Island, 1998.

University of Colorado Health Sciences Center - Department of Pharmacology, Denver, Colorado, 1998.

Stanford University School of Medicine - Frontiers of Neuroscience Seminar Series, Stanford, California, 1998.

Eli Lilly and Company, Indianapolis, Indiana, 1998.

Colorado State University - Molecular, Cellular and Integrative Neuroscience Program, Fort Collins, Colorado, 1998.

Johns Hopkins University School of Medicine - Department of Neuroscience, Baltimore, Maryland, 1999.

Hungarian Academy of Sciences - Institute of Experimental Medicine, Budapest, Hungary, 1999.

Gordon Research Conference - Mechanisms of Membrane Transport, Plymouth, New Hampshire, 1999.

Symposium in honor of Professor Denis Baylor - Neural Signaling and Beyond, San Francisco, California, 2000.

University of Arizona - Neuroscience Program, Tucson, Arizona, 2000.

Baylor College of Medicine - Department of Biochemistry, Houston, Texas, 2000.

Harvard Medical School - Department of Ophthalmology, Boston, Massachusetts, 2000.

Brown University - Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island, 2001.

California Institute of Technology - Division of Biology, Pasadena, California, 2001.

Weill Medical College of Cornell University - Department of Pharmacology, New York, New York, 2002.

Oregon Health & Science University - Neurological Sciences Institute, Beaverton, Oregon, 2002.

Columbia University College of Physicians and Surgeons - Department of Biochemistry and Molecular Biophysics, New York, New York, 2002.

Gordon Research Conference - Cyclic Nucleotide Phosphodiesterases, South Hadley, Massachusetts, 2002.  

Reed College - Department of Chemistry, Portland, Oregon, 2002.

Brigham Young University - Department of Physiology & Developmental Biology, Provo, Utah, 2002.

Chemica Technologies, Inc., Bend, Oregon, 2003.

Western Pharmacology Society Meeting, Symposium - Compartmentation of Signaling in Cardiac Myocytes, Lake Tahoe, Nevada, 2003.

University of Pittsburgh School of Medicine - Department of Cell Biology and Physiology, Pittsburgh, Pennsylvania, 2003.

Brown University - Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island, 2003.

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, 2003.

Portland State University - Department of Chemistry, Portland, Oregon, 2003.

HHMI Workshop - The Biochemistry of Single Cells, Chevy Chase, Maryland, 2004.

Oregon Health & Science University - OGI School of Science & Engineering, Department of Environmental and Biomolecular Systems, Beaverton, Oregon, 2005.

University of California at Davis - Distinguished Lecture Series, Department of Physiology and Membrane Biology, Davis, California, 2007.

Second International Conference on Anchored cAMP Signaling Mechanisms, Portland, Oregon, 2007.

HHMI Janelia Farm Research Campus - Chemistry in Neuroscience Symposium, Ashburn, Virginia, 2007.

University of Colorado Denver - Department of Physiology and Biophysics, Aurora, Colorado, 2008

Lewis & Clark College - Department of Chemistry, Portland, Oregon, 2008.

Willamette University - Department of Chemistry, Salem, Oregon, 2008.

University of Alabama at Birmingham - Vision Science Research Center, Birmingham, Alabama, 2008.     

BIT Life Sciences, International Drug Discovery Science and Technology - Session on Receptors and Ion Channel Based Drug Design and Development, Shanghai, China, 2009.

Brown University - Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island, 2011.

12th International Congress on Amino Acids, Peptides and Proteins - Session on Ion Channel Inhibitors, Beijing, China, 2011.

International Society for Heart Research/Western Pharmacology Society (joint meeting), Banff, Alberta, Canada, 2012.