David Manna, PhD
Assistant Professor of Microbiology and Immunology, Department of Basic Biomedical Sciences
Dr. Manna's interest in microbiology, especially regarding viruses, was ignited during his first undergraduate research experience in the lab of Dr. Dan Simmons at the University of Delaware. They used a small DNA virus, SV40, as an in vitro system to study the early molecular steps of DNA replication. Dr. Manna then took this molecular and microbiology experience with him to Penn State where he worked in Dr. Kouacou Konan's lab studying Hepatitis C Virus genome replication and virus production. After graduation, he took a teaching-focused Post-doc with the Wilkes University Biology Department that gave him valuable experience in the scholarship of teaching and which led him to a career as a medical educator.
Immunology (BSCI 612 M)
Medical Microbiology and Immunology 1&2 (BSCI 624 M, 636 M)
Saidman Post-doctoral Fellow, Wilkes University Biology Department (Fall 2013- Summer 2014)
HHMI Post-doctoral Fellow, Wilkes University Biology Department (Spring 2012- Summer 2013)
Ph.D., Biochemistry, Microbiology & Molecular Biology; Pennsylvania State University, University Park, PA (2011)
M.S., Biotechnology; University of Delaware, Newark, DE (2006)
B.S., Biotechnology; University of Delaware, Newark, DE (2004)
Assistant Professor of Microbiology, West Virginia School of Osteopathic Medicine (2014-2016)
Areas of Research/Interest:
My research interests involve the mechanisms by which plus-strand RNA viruses, such as HCV, alter the intracellular environment to promote viral genome replication and infectious particle assembly.
1) Han Q.*, Manna D.*, Belton K., Cole R., and Konan KV. 2013. Modulation of hepatitis C virus genome encapsidation by nonstructural protein 4B. J Virol. 87(13): 7409-7422. * QH and DM contributed equally to this work.
2) Manna D., Aligo J., Xu C., Park W.S., Koc H., Do Heo W., and Konan K.V. 2010. Endocytic Rab Proteins are Required for Hepatitis C Virus Replication Complex Formation. Virology. 398(1): 21-37.
3) Han Q., Aligo J., Manna D., Belton K., Chintapalli SV., Hong Y., Patterson RL., van Rossum DB., and Konan KV. 2011. Conserved GXXXG- and S/T-like Motifs in the Transmembrane Domains of NS4B Protein are Required for Hepatitis C Virus Replication. J Virol. 85(13): 6464-6479.
4) Guevin C., Manna D., Belanger C., Konan K.V., Mak P., and Labonte P. 2010. Autophagy Protein ATG5 Interacts Transiently With the Hepatitis C Virus RNA Polymerase (NS5B) Early During Infection. Virology. 405(1): 1-7.
5) Aligo J., Jia S., Manna D., and Konan K.V. 2009. Formation and Function of Hepatitis C Virus Replication Complexes Require Residues in the Carboxy-Terminal Domain of NS4B Protein. Virology. 393(1): 68-83.
6) Wang W., Manna D., and Simmons D.T. 2007. Role of the Hydrophilic Channels of Simian Virus 40 T-Antigen Helicase in DNA Replication. J Virol. 81(9): 4510-4519.