Gurjinder Kaur, PhD

Assistant Professor of Physiology, Department of Basic Biomedical Sciences

Dr. Gurjindur Kaur Faculty Profile Photo
  • Office: 60 Prospect Avenue, 2nd Floor, Room 252
  • Campus:
    Touro College of Osteopathic Medicine - Middletown
  • Phone:
    (845)648-1255
  • Email:
    gurjinder.kaur14@touro.edu

Courses Taught:

Medical Physiology I & II

Education/Training:

Ph.D. Guru Nanak Dev University, India 1998

Postdoctoral Fellow, West Virginia University, 2002-2004

Research Associate, Center for Neuroscience, Miami University, 2004-2005

Research Scientist at Nathan Kline Institute for Psychiatric Research/NYU School of Medicine, 2005-2018

Academic Appointments

Assistant Professor of Physiology

Professional Affiliations

Nathan Kline Institute for Psychiatric Research, Orangeburg, NY

Orange Regional Medical Center, Middletown, NY

Society for Neuroscience

Trisomy 21 Research Society

Awarded Research Grant Fellowship for Graduate research proposal, Indian Council of Medical Research, 1993-1997.

Young Scientist Travel Award, International Narcotics Research Conference 2000 & 2002.

Investigator-Initiated Research Grant Funding, Alzheimer’s Association 2011-2014.

Areas of Research/Interest

Pathobiology of neurodegenerative changes and behavioral dysfunctions in Alzheimer's disease and Down's syndrome. Studying pathogenic factors that contribute to the development of Alzheimer’s disease employing molecular, biochemical, cellular methods, and transgenic mouse models.

Selected Publications

Kaur, G. and Salm, A.K. (2008) Blunted amygdalar anti-inflammatory cytokine effector response to postnatal stress in prenatally stressed rats. Brain Res. 1196: 1-12, PMID: 18234159.

Kaur, G., Hrabetova, S., Nicholson, C., Guillfoyle, D.N. and Hrabe, J. (2008) Characterizing molecular probes for diffusion measurements in the brain. J Neurosci. Meth. 171(2): 218-225, PMCID: PMC2486452.

Kaur, G., Mohan, P., Pawlik, M., DeRosa, S., Fajiculay, J., Che, S., Grubb, A., Ginsberg, S.D., Nixon, R.A., Levy, E. (2010) Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. Am. J. Pathol. 177(5): 2256-67, PMCID: PMC2966785.

Gauthier, S., Kaur, G., Mi, W., Tizon, B., Levy, E. (2011) Protective mechanisms by cystatin C in neurodegenerative diseases. In: Special Issue title: "Late onset neurodegenerative diseases: current advances and new hypotheses". Siamak Tabibzadeh, Editor-in-Chief. Front Biosci (Schol Ed). 3:541-554, NIHMSID:269175.

Kaur, G., Choi J.H., Mazzella, M.J., Morales-Corraliza, J., Levy, E., Mathews, P.M. (2013) Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice. J Alzheimers Dis. 34(3):691-700, PMCID: PMC3616896.

Kaur, G., Sharma, A., Xu, W., Gerum, S., Alldred, M.J., Subbanna, S., Basavarajappa, B.S., Pawlik, M., Ohno, M., Ginsberg, S.D., Wilson, D.A., Guilfoyle, D.N., Levy, E. (2014) Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome. J Neurosci. 34(15):5099-106. PMCID: PMC3983795.

Kaur, G., Pawlik, M., Gandy, S.E., Ehrlich, M.E., Smiley, J.F., Levy, E. (2016 ) Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry. Oct 25. PMID: PMC27777419.

Gauthier, S.A., Pérez-González, R., Sharma, A., Huang, F., Alldred, M.J., Pawlik, M., Kaur, G., Ginsberg, S.D., Neubert, T.A., Levy, E. (2017). Enhanced exosome secretion in Down syndrome brain - A protective mechanism to alleviate neuronal endosomal abnormalities. Acta Neuropathologica Communications.  Aug 29;5(1):65. PMID: 28851452

Kaur G, Gauthier SA, Perez-Gonzalez R, Pawlik M, Singh AB, Cosby B, Mohan PS,

Smiley JF, Levy E. (2018). Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis. Dec;120:165-173. PMID:30176349

Grants/Funding

Awarded Research Grant Fellowship for Graduate Studies, Indian Council of Medical Research, 1993-1997.

Investigator-Initiated Research Grant Funding, Alzheimer’s Association 2011-2014.